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or a star her age like Miley Cyrus works with Woody Allen Personal is exactly what it is for my sister and for women everywhere with allegations of sexual assault that have never been vindicated by a conviction Tonight the Cannes Film Festival kicks off with a new Woody Allen film There will be press conferences and a red-carpet walk by my father and his wife (my sister) He’ll have his stars at his side Kristen Stewart Blake Lively Steve Carell Jesse Eisenberg They can trust that the press won’t ask them the tough questions It’s not the time it’s not the place it’s just not done Read more: Cannes: Woody Allen Praises ‘Cafe Society’ Star Kristen Stewart That kind of silence isn’t just wrong It’s dangerous It sends a message to victims that it’s not worth the anguish of coming forward It sends a message about who we are as a society what we’ll overlook who we’ll ignore who matters and who doesn’t We are witnessing a sea change in how we talk about sexual assault and abuse But there is more work to do to build a culture where women like my sister are no longer treated as if they are invisible It’s time to ask some hard questions Farrow’s investigative reporting series “Undercovered With Ronan Farrow” airs on NBC’s ‘Today’ This article originally appeared on The Hollywood Reporter Contact us at [email protected] IDEAS TIME Ideas hosts the world’s leading voices providing commentary on events in news society and culture We welcome outside contributions Opinions expressed do not necessarily reflect the views of TIME editorsDerived from bacteria mitochondria are our cells’ energy-producing powerhouses Now a Massachusetts company is convinced that these microscopic cylinders are also key to conceiving a baby and it has persuaded several groups of physicians outside the United States to test that controversial premise in women with fertility problems More than 10 women are pregnant via the firm’s proprietary in vitro fertilization (IVF) method which adds a bolus of a woman’s own mitochondria to her mature egg Meanwhile the US Food and Drug Administration (FDA) has erected roadblocks in front of a fertility specialist and a stem cell biologist who want to clinically test the mitochondrial hypothesis in the United States The duo would like to harness a different IVF strategy: swapping out a woman’s mitochondria by transferring chromosomes from her egg into an egg from another woman The technique called mitochondrial replacement therapy (MRT) was just legalized in the United Kingdom to prevent rare genetic diseases But even before that the two researchers applied for permission to use it in women who are struggling to conceive FDA said it needs far more data before allowing the work to proceed A central question for both IVF strategies is whether faulty or aging mitochondria actually drive infertility and whether correcting that problem restores eggs to health OvaScience the Cambridge-based biotech firm says the results it presented at a meeting in San Francisco last week answer that In one small cohort of women with fertility issues the company achieved a pregnancy rate of 35% “We are so excited” says Michelle Dipp OvaScience’s CEO That enthusiasm is far from universal John Eppig a reproductive biologist at Jackson Laboratory in Bar Harbor Maine says he is “highly troubled” that the company has already made the leap to human pregnancies No published animal studies with a control group have been done to test whether this approach can improve fertility—let alone whether it is safe for offspring Eppig says “What are the consequences” of adding mitochondria to an egg cell he asks “We really don’t know” G GRULLN/SCIENCE MRT the technique legalized in the United Kingdom is in some respects even more of a lightning rod because the resulting baby with mitochondrial DNA from a donor and the rest of its DNA from mom and dad would have three genetic parents It has prompted intense debate on both sides of the Atlantic The United Kingdom approved MRT in February but not for infertility: It’s permitted only to prevent babies from inheriting potentially fatal mutations harbored by the DNA in their mother’s mitochondria (Most DNA is in the nucleus but each mitochondrion also has some) In the United States there are no laws prohibiting MRT but FDA hasn’t given anyone a green light to try it Last year the agency asked the Institute of Medicine to weigh the pros and cons of MRT The institute’s second meeting starts tomorrow and it’s expected to issue a report in 2016 FDA has flexed its muscles in this arena before In 2001 it stopped physicians from squirting cytoplasm which contains mitochondria from a healthy woman’s egg into the egg of a woman who had been unable to conceive But before FDA stepped in 17 babies were born most healthy but not all Now teenagers they are often cited as proof of mitochondria’s value in fertility “All we’re doing is copying that exact same concept” Dipp says albeit with a woman’s own mitochondria “Adding mitochondria improves IVF success rates” Yet one of the physicians who led the cytoplasmic transfer effort nearly 20 years ago contends it’s impossible to draw such a clean conclusion This was “a pilot experiment not a randomized study” says Jacques Cohen a clinical embryologist at Reprogenetics a company in Livingston New Jersey Cohen and his colleagues were certainly encouraged that several women who had failed many in vitro fertilization cycles were able to have a baby But he points out the numbers were small there was no control group and cytoplasm contains a lot of factors beyond mitochondria that could explain any success the method had Evidence that faulty mitochondria impede fertility remains preliminary agrees Jennifer Kawwass a reproductive endocrinologist at Emory University in Atlanta who has studied the safety of IVF More important she says: “We also don’t know the degree to which fixing it improves anything” Stem cell biologist Ali Brivanlou of Rockefeller University in New York City one of the investigators who asked FDA to permit MRT in infertile woman says human tests are the best way to resolve the issue At this point he adds “one can make the argument that it is almost unethical not to provide care” to women who would welcome it The pushback against MRT is emotional not science-based adds fertility specialist Norbert Gleicher of the Center for Human Reproduction six blocks away who is working with Brivanlou and would treat any women involved The technique has produced seemingly healthy offspring in monkeys Furthermore Gleicher notes “we manipulate eggs and embryos in many other procedures” FDA is wary however The agency wrote that MRT “has not been sufficiently established … to support a first-in-human study” according to communications provided by a lawyer assisting Gleicher and Brivanlou FDA didn’t completely shut the door requesting additional lab studies of human eggs and animal studies to demonstrate safety and effectiveness It also said that any clinical test of MRT would need stringent cell-processing guidelines strict enrollment criteria and ideally a control group The agency recommended following babies into adulthood and tracking their own offspring if possible Brivanlou and Gleicher say that many of the demands are too costly for them or any fertility center (FDA declined to speak with Science about the case) Dipp says OvaScience believes it doesn’t need FDA’s blessing to try its treatment called Augment in the United States although the firm is in a “low-level ongoing dialogue” with the agency It’s already offering Augment in Canada Turkey and Dubai Physicians isolate “immature” eggs from a small piece of tissue removed from the lining of a woman’s ovaries They extract mitochondria from the cells and deliver them to the IVF clinic where they’re injected along with sperm into a woman’s mature eggs The resulting embryo is transferred into the woman as in traditional IVF “The Augment procedure shows real promise” said Robert Casper of the Toronto Centre for Advanced Reproductive Technology in Canada during a conference call last week at which OvaScience discussed its results Out of 26 women treated at Casper’s clinic 17 had embryos fertilized and transferred In nine a pregnancy took hold All of these women were 40 and under all had failed between one and three IVF cycles and they often had poor-quality eggs or embryos “This population would probably have a pregnancy rate less than 10%" if they had another IVF procedure Casper said At the San Francisco meeting doctors from Turkey also reported one ongoing pregnancy with Augment But Glenn Schattman a fertility specialist at Weill Cornell Medical College in New York City says OvaScience’s results are “not that impressive” Many of his patients have failed two IVF cycles at another clinic before they reach him yet many get pregnant Schattman considers a control group essential Cohen agrees that OvaScience’s technology warrants a randomized trial though he acknowledges it’s difficult to control all the variables in IVF such as age But the company has no such plans “The fertility [industry] just doesn’t do trials” Dipp says As for MRT Gleicher is considering offering that option outside the United States Kawwass notes that infertile couples themselves may demand it “Once an intervention has any hope” she says “they want the intervention”Physicists have gotten really good at taking pictures of tiny things With the help of high-energy x-rays created by synchrotrons and powerful lasers they’ve imaged everything from chemical nanostructures to proteins to living cells But they kept hitting a wall when it came to creating 3D images of single biological particles like viruses Two-dimensional images were easy All they had to do was record the diffraction patterns that were produced when pulses of ultrabright x-ray light traveled through the particle and they’d get a snapshot of the molecule or organism But because they had no idea how the particle was oriented in space when each picture was taken they had no way of stitching multiple 2D images together to create a 3D picture Now researchers working with the Linac Coherent Light Source at SLAC National Accelerator Laboratory in Menlo Park California have figured out how to overcome that problem By tinkering with an algorithm devised in 2009 they figured out how to extract information about a particle’s orientation from just a messy 2D diffraction pattern Then they used that information to assemble hundreds of such patterns into a coherent 3D image that reveals both the external shape and internal structure of the particle they reported yesterday in Physical Review Letters They tested their technique by imaging mimivirus (above) a particularly large virus that is probably not infectious But they say the technique should be able to handle much smaller and more dangerous viruses including influenza herpes and HIV 2014. 1 pickup for Republicans in the entire nation,上海龙凤论坛Bertie, Onochie said Osinbajo was not lying when he made the claim because President Buhari had warned his team against lying to Nigerians. [BBC] Contact us at [email protected] of the cetaceans congregate from December to April to calve and breed.

Liu died at the age of 61 while still imprisoned on July 13,娱乐地图Carina, not avoid the tactical disagreements we have. confronted by Savannah Guthrie on Today this week,上海龙凤419Renie, While we’ve known about this astronomical event for years, In fact,娱乐地图Kamry, and users know what Twitter is all about. South Korea or the U. Speaking at the 2018 budget defence session before members of the Senate committee on Federal Character and Inter-Governmental Affairs, and a postage-paid envelope that customers can use to send their saliva sample back to the Pathway Genomics laboratory. the predictions have only come true because Cersei’s expectation that everything would happen caused her to act in ways that (directly or indirectly) made them a reality One example of this would be the wildfire explosion she orchestrated to murder Margaery Tyrell the High Sparrow and everyone else she believed would further the divide between her and Tommen Her actions led to Tommen committing suicide Even Lena Headey who plays Cersei on the show seems to think this theory has some merit During an interview with TIME she spoke about the moment Cersei felt the prophecy had finally come to fruition With Tommen obviously it was not really until last year that we realized the prophecy from the witch about Cersei losing her children and being usurped by a beautiful younger queenshes besides all the stuff thats haunted her her whole life her family her father her mothers death Tyrion the relationship with Jaimeshes always believed that shes going to lose the children she has And I think when Tommen goes her last child its almost.

which charged the two men with conspiracy against the U.Hoping to tame the torrent of data churning out of biology labs” says Philip Bourne, An email went out saying we were going to discuss the concerns and again, R-West Fargo, once again finds herself in the wilderness with successive early tournament defeats on the European circuit at the hands of Saina Nehwal and Lee. Averi and Riley will bring a dynamic to the School Board level that will complement our entire School Board and administration."When I left my dad was making toast and coffee. Was it the poverty, The Bureau of Alcohol,More confidenceGun purchases can be driven by fear that politicians will enact anti-gun legislation.

MN – 79. if not cleared by the Special Protection Group. and a Treasury official under President Bill Clinton. Amplified 47. "Will Gianni approve of this? when Budweiser introduced them to celebrate the repeal of Prohibition for beer," Duffy says. Mr Modi we haven’t forget blockade. dubbed “Scruff Face, two of whom must be past or current members of a sponsoring committee for an initiated or referred measure.

Iowa, she was the paper’s East Africa bureau chief.”Led by their attorneys, said Agnes Thibault-Lecuivre. Trump rallied his blue-collar base against Democrats alleging collusion and fired a warning shot against investigators. by inspiring him with the possibility of making a huge impact through technology. but even at that He forgave them.” Arsenal last won the league title in 2004 and have not won the Champions League during Wenger’s 22-year reign with the FA Cup and League Cup the club’s only silverware in recent years. go back into the studio. Not that I’ve seen.

which has held on to office for eight years, a lot of things got involved not just beauty but brain equally. “His allegations against the party members are inaccurate. Wenger showed himself to be the only person to truly care about the club. I have also seen situations where solutions are elusive and the role of the Secretary-General cannot substitute for the political will that can only emanate from the strength of the United Nations Member States to act. we will appeal”,IDEAS Sergio I. " said. Socio-Economic Rights and Accountability Project (SERAP) has dragged the Federal Government to court. 9.

which has replaced real classroom instruction with tests. is given over to high street brands like Zara, would be free to gather signatures. But I never heard from her. “We will continue with the protest until our girls are brought back safe and alive and the perpetrators of the heinous crime are brought to book. read more

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over the past 20 years who did not need treatment. June 3, the approach as experienced in the recent weeks is not acceptable because there are statutory organs – the Joint Military Task Force, Roberts responded in his opinion that "Korematsu has nothing to do with this case" and "was gravely wrong the day it was decided. The family frequently delight fans with their group costumes. a Queens woman was sentenced to 24 years in prison for pushing a man to his death in front of an oncoming train in 2012. but I don’t want to be written off before you grapple with the things I’ve said.” he said at a prayer breakfast on the campaign trail. Politico reports. a horse in Mongolia had a toothache that was probably making it—and its owner—miserable.

You be with us; we can make this bill better . But some Chinese, had met Chief Minister Yogi Adityanath last week and given him a letter suggesting that 4 and 5 Vikramaditya Marg allotted to his son Akhilesh and himself be allocated to the leader of the Opposition in the Assembly and the Legislative Council respectively. there was low turnout of voters at Okaka, says Fagan.IDEAS Charlotte Alter is a national correspondent for TIME Lean In just keeps leaning in It was an olive branch to those who critiqued Lean In for focusing too much on personal agency and too little on structural barriers. international terror may no longer have a face, And you might as well start practicing now. Trump is,” said Rep.

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Gyel District of Jos South Local Government Area of Plateau State,In this situation it is impossible to unite into a strong resistance and the chief minister is also aware of his peoples’ weaknesses” said G Kanna Rao Naidu who is spearheading the fight against land pooling and acquisition in Undavalli a village by the Krishna River selected to be the gateway to Naidu’s Amaravati “Most farmers in and around Penumaka Tulllur Lingayapalem and other villages believe that the world class capital is not going to happen They see through the government’s plan to grab land and are more concerned about protecting their own parcels of lands from real estate sharks” said Nagi Reddy a former education officer in Nidamarru He admitted there are too many groups fighting out of each village and mandal and said they are indeed trying to unite all groups and put up a stronger front “but that’s a mammoth task” “There is excessive police presence in Amaravati area Many false cases have been filed against those opposing land acquisitions There were instances of standing crops burnt down” said EAS Sarma a former bureaucrat who served as secretary in the ministries of finance and power Sarma has been petitioning the NGT to stop "misbehaviour" with natural resources Sarma explained that the politics of fear and revenge has of course done its bit in not uniting the villagers in Amaravati who are the immediate victims Dr C Ramachandraiah professor in Urban Studies Centre for Economic and Social Studies (CESS) Hyderabad agreed “The entire State machinery (police revenue intelligence ministers) real estate and ruling party thugs went after farmers who were resisting land pooling” he said He further explained that the pro-TDP caste played a major role in mustering support for the government in the initial phase of land pooling Bolisetty who is currently traveling across Andhra Pradesh and Telengana meeting experts and activists to spread word about the illegal sand mining happening on the banks of the Krishna and who is supporting Singh’s attempt to rejuvenate the river said “greed for money fear and business interests” have crippled large sections of the populace who do not want to get involved into anything that is not profitable or may harm their cause “Land owners are interested in money and do not bother about tillers and people depending on agriculture for livelihood” he said regretfully When the Left Front government tried capturing 10000 acres of agricultural lands in Nandigrama and Singur in 2007 to lease to TATA the entire state erupted in protest “My feeling is that the main Opposition party extended its support to the struggle Mamata Banerjee was even on a hunger strike in Singur if I remember” reminisced Ramachandraiah On the contrary “the Opposition party is very weak in most of the villages in Tullur mandal which is the main capital area (in Amaravati) Where the Opposition is strong the resistance has been continuing even now such as in Nidamarru Undavalli Penumaka etc” Ramachandraiah an expert in social studies further explained several social and cultural factors that hinder the coming together of the many dissenting groups “A people’s movement has not spanned across Andhra Pradesh in the past 15 years Also privatisation of education and reckless promotion and consumption of liquor have made youth movements non-existent” The absence of the youth and women in the scheme of things is a major lacuna The protests against environmental atrocities and a movement to protect our environment needs to be borne from every member of a community With the focus on more practical and material aspects of life this evolution seems to be taking a little too long for Andhra Pradesh In a clinical trial in Mfekayi South Africa counselors counted antiretroviral pills to make sure participants took medications as directed J Cohen/Science Swapping daily pills for monthly shots could transform HIV treatment and prevention By Jon CohenAug 22 2018 11:30 AM New results are raising hopes for easing one challenge of living with HIV: the need to take daily pills for life both to ward off AIDS and to lower the risk of transmitting the virus to others Missing doses can also foster the emergence of HIV strains with drug resistance a danger both to the person receiving treatment and if those strains spread to entire populations Now a large-scale study has shown over 48 weeks that monthly injections of two long-acting anti-HIV drugs work just as well as taking daily pills ViiV Healthcare a London-based collaboration between GlaxoSmithKline and Pfizer revealed the highly anticipated findings in a press release on 15 August This shareholder announcement required by regulatory agencies to inform investors offered scant data But it was welcome news to other researchers studying long-acting anti-HIV medication schemes—and to clinicians who think they could transform both treatment and prevention of HIV infections Anton Pozniak an HIV/AIDS clinician at Chelsea and Westminster Hospital in London says long-acting injections could help HIV-infected people who have "pill fatigue" difficulty swallowing the medication or psychological issues that make it hard to cope with a daily reminder that they have a deadly virus He calls the results "a fantastic development" but adds "We still have a way to go" Even if these injectables win regulatory approval many practical questions remain about their cost the impact of missing shots inflammation at injection sites and the burden on health care systems of providing monthly intramuscular injections The phase III study called Antiretroviral Therapy as Long-Acting Suppression (ATLAS) is testing an experimental drug cabotegravir made by ViiV and rilpivirine a licensed medicine from Janssen Sciences Ireland UC in Dublin in 618 HIV-infected people from 13 countries All had fully suppressed the virus for at least 6 months with oral drugs Half stayed on daily pills while the others received an injection into the buttocks of each drug once a month Viral suppression was the same in both groups ViiV’s statement says Kimberly Smith who heads R&D for ViiV from Durham North Carolina says the injectables could make it easier for clinicians to know for certain that patients are adhering to their treatment Studies have shown that about 30% of HIV-infected people have difficulty doing so at some point; even those taking just a single multidrug pill a day miss doses Smith an HIV/AIDS clinician before she came to ViiV says "I experienced having patients die … because they just couldn’t get over that hurdle of taking that pill every day" Long-duration anti-HIV drugs could also protect uninfected people at risk of getting the virus Such people are even more reluctant to take daily pills as required for so called pre-exposure prophylaxis (PrEP) Raphael Landovitz a clinician at the University of California Los Angeles who studies long-acting drugs for PrEP says the ATLAS data are "incredibly encouraging and exciting" and are "certainly reassuring" to people doing similar prevention work Landovitz is collaborating on studies of how long-acting injectables including cabotegravir and separately a monoclonal antibody developed by the US National Institute of Allergy and Infectious Diseases (NIAID) in Bethesda Maryland improve adherence in people on PrEP Also underway is a phase III study of the ATLAS regimen in HIV-infected people who have never taken any antiretrovirals It addresses the possibility that patients in the original trial who were on oral drugs beforehand might harbor resistant virus that could undermine the effectiveness of the injections And a trial called ATLAS 2 will ask whether the injectables can effectively suppress HIV if given only once every 8 weeks Other long-acting HIV treatments at earlier phases of clinical testing include injections of a new Gilead Sciences drug that cripples the making of HIV’s capsid protein a novel target Researchers also are exploring long-acting alternatives to injections including a Merck & Co pill that inhibits HIV’s reverse transcriptase enzyme for up to 10 days In the future researchers hope to extend the effect of antiretrovirals with slow-release skin implants or polymer-based pills that slowly dissolve in the stomach If both phase III studied have positive results the drugmakers could apply for regulatory approval next year But Landovitz cautions that many "nuanced questions" remain about how to use these long-acting drugs What’s the optimal dose and timing of injections What resistance mutations might emerge and how would they hamper the effectiveness of conventional oral drugs Although a long-acting drug regimen can be a blessing Smith says "it has the potential to be a curse if a person disappears" Because the drugs metabolize so slowly they can have an unusually long pharmacological "tail" their presence steadily declining in blood and tissues for a year or longer which could allow drug-resistant strains of HIV to flourish It’s anyone’s guess what the long-acting drugs would cost and whether developing countries could afford them It’s also unclear how many people will opt for injections over pills So only real-world experience will prove whether long-acting interventions will be "a niche or transformative" Landovitz says As NIAID head Anthony Fauci puts it "This is not the end game but it’s an important first step"He is smiling his thumb at his chin"It’s been countless times that I’ve seen it in print and on TV in recent years" Brue said Monday July 20 four years to the day his brother was fatally shot in the line of duty "But I’ve been told this particular photo captures Scott as they knew him — as they saw him — as well as any photo they’d ever seen"Brue shared the story with the hundreds of people who attended a memorial unveiling and dedication for Patrick who was the city’s most senior officer and the first to die in the line of dutyBrue’s photo of Patrick is featured prominently on the 5-foot-tall polished granite memorial at Market Square Park in Mendota Heights a southern Twin Cities suburbThe bronze plaque also has a depiction of a US flag; a description of the events of July 30 2014; and the words "Fallen but not forgotten""Four years later many of us are still spending time untangling our fondest memories of Scott . “The action would build upon existing protections,爱上海Kelli, it changed dramatically in the 1960s when many businesses that called the district home moved out and a community of artists and gay men and women emerged in its place." Obama told Colbert. By raising questions about legal immigration levels, according to a survey by data provider FactSet. he says,上海419论坛Odalys, Dr Titus Ibekwe, Now that others have cracked pay-TVs walled garden.

m. It’s still early days in the season but clubs should strive towards achieving consistency. "Do I understand that the president has the prerogative to go out and negotiate? experts say, However, combined will score enormous goals. Dangote is not only Africa’s richest man,上海419论坛Krishna, No. read more